Fannish 50 Challenge 2025: Post # 28: due South fandom: annual Ray Vecchio Day
Sep. 20th, 2025 04:54 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png)
Posting to the collection is now open at Ray Vecchio Day 2025 Collection on AO3.
TLDR: hypermobile Ehlers Danlos Syndrome, with known immune system crossovers, turns out to have weird immune system proteins on top of all the other weirdness.
Interesting new hEDS paper I saw mentioned on FB today,
"Proteomic analysis revealed 35 differentially expressed proteins in hEDS, with 43% involved in the complement cascade and 80% linked to immune, coagulation, or inflammatory pathways. ... Cytokine profiling revealed alterations in nodal immune cell mediators in hEDS patients, supporting a model of dysregulated inflammatory response. Our findings indicate a systemic immune dysregulation, particularly involving the complement system and profibrotic cytokines, as a common feature in hEDS pathophysiology."
https://www.ehlers-danlos.com/exciting-new-research-sheds-light-on-heds-biology/
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